Thursday, January 31, 2013

NLRB tells union to back off Wal-Mart protests

(AP) ? The National Labor Relations Board and a union have agreed to settle a complaint Wal-Mart filed over union protests at stores during a busy holiday shopping time.

Wal-Mart Stores Inc. said Thursday that the National Labor Relations Board action should end picketing by the United Food and Commercial Workers union that has irritated company officials.

The union has organized pickets on the day after Thanksgiving, one of the busiest shopping days of the year, known as "Black Friday."

The agreement will stop picketing and "confrontational conduct" at Wal-Mart facilities for at least 60 days.

UFCW organizers have been working to unionize Wal-Mart workers and have campaigned for the company to pay its employees more and offer better benefits.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-01-31-Wal-Mart-Union/id-a4c3ce67bc3742109384839c3b2bd657

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Wednesday, January 30, 2013

Syrian state media report airstrike by Israeli military

JERUSALEM ? Amid rising fear that Syrian President Bashar Assad could lose control of his nation?s stockpiles of chemical and advanced weapons, Israel bombed and destroyed a military research center outside Damascus, the capital, Syrian state media reported Wednesday.

Israeli and U.S. military and government officials declined to comment on the report.

If it occurred, the attack would mark Israel?s most aggressive military strike against its neighbor during the Syrian uprising against Assad's rule that began nearly two years ago.

Earlier in the day, international news agencies and Arab news outlets reported that the Israeli strike had targeted a weapons convoy along the Syrian-Lebanese border as it attempted to deliver cargo to the militant group Hezbollah. Those reports could not be confirmed. Syrian officials denied the reports of a convoy as ?baseless.?

Israeli officials have been voicing concern in recent days that Syria?s advanced weapons might fall into the hands of militant groups that could use them against Israel.

Israeli Prime Minster Benjamin Netanyahu raised the issue during a Cabinet meeting this week and officials have repeatedly said that any transfer of such weapons outside Syria might trigger a military response.

According to Syrian TV, the research facility and an adjacent building were destroyed in the dawn attack Wednesday. Two people were killed and five were injured, Syrian news reports said.

It was unclear what sort of military research was being carried out in the center, in Jamraya, northwest of the capital. There were no initial reports of chemical contamination in the area.

Syrian officials characterized the center as scientific and said Israel?s ?blatant aggression? proved that it has been behind the effort to oust Assad, according to statement from the Syrian military, carried by the official Syrian Arab News Agency.

?It has become clear to everyone that Israel is the motivator, beneficiary and sometimes executor of the terrorist acts that target Syria and its resistant people,? the statement said.

To date Israel has tried to steer clear of the Syrian conflict, fearing that any actions it might take, such as supporting opposition forces or launching a military strike, might backfire or become a propaganda coup for Damascus.

That very issue might lead the Syrian government, which has long claimed that U.S. and ?Zionist? forces are behind the rebellion against Assad, to accuse Israel of attacking its territory.

Each side in the Syrian conflict has portrayed itself as an implacable enemy of Israel.

There is also concern that an Israeli strike could drag others into the Syrian conflict. Iran, Syria?s close ally, said early this week that any foreign attack against Syria would be regarded as an attack on Iran.

In addition to chemical weapons, Israeli officials have been particularly worried about Syria?s stockpile of Russian-made SA-17 anti-aircraft missiles. If such weapons were obtained by the militant Hezbollah movement, it would weaken Israel?s regional military power and hinder its ability to launch airstrikes in Lebanon.

?The initial speculation was about chemical weapons, but Israel is deeply concerned about Hezbollah acquiring this kind of advanced anti-aircraft missile,?? said Jonathan Spyer, senior research fellow at the Center for Global Research in International Affairs in Herzliya, Israel. ?It would transform Hezbollah?s game and potentially end Israel?s air superiority over Lebanon. This is entirely about Hezbollah, not about Syria.?

Officials in Lebanon denied knowledge of any Israeli attack, but complained that Israeli jets had violated their airspace for several hours, beginning Tuesday afternoon and continuing until Wednesday morning. Though Israel routinely flies over Lebanon for reconnaissance missions to keep a close eye on Hezbollah's arms stocks and movements of weapons, the activity overnight was reportedly heavier than usual.

It is often Israel?s policy to refuse to confirm or deny its activities in the region, partly out of a belief that silence might reduce the pressure on its enemies to react or retaliate.

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?

Source: http://www.latimes.com/news/la-fg-wn-syrian-state-media-airstrike-israel-20130130,0,2334015.story?track=rss

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Palestinian fighter, rebel dies in Damascus

DAMASCUS, Syria (AP) ? A hard-line Palestinian military commander who rebelled against leader Yasser Arafat to form his own rival party died in Damascus on Tuesday, according to his representatives and hospital officials. Said Musa Maragha, better known by his nom de guerre, "Abu Musa," was 86.

They said Maragha died of cancer.

Maragha, a Jordanian of Palestinian descent, defected from the Jordanian army in 1970 over tensions between the military and Palestinian fighters who were using the kingdom as a base to carry out attacks against Israel.

Palestinian fighters were pushed out of Jordan in 1971 in battles with Jordanian forces that killed thousands, mostly Palestinians, later known as "Black September."

Many fighters, including Maragha, fled to Lebanon.

There he joined the Fatah movement, headed by charismatic leader Arafat. Fatah at the time was aiming to destroy Israel and create a Palestinian state in its place, demanding the return of hundreds of thousands Palestinian refugees who fled or were forced from their homes during the 1948 Mideast war surrounding the creation of the Jewish state.

Decades later, the movement changed its goal to establishing a Palestinian state alongside Israel in territories seized in the 1967 Mideast war ? the West Bank, Gaza Strip and east Jerusalem, while still demanding the return of the refugees to Israel.

Maragha quickly rose through the ranks of ragtag Palestinian fighting forces. By 1976, he was Fatah's chief military operative in south Lebanon, where Palestinians had carved out an enclave to attack neighboring Israel.

Maragha also involved Palestinians in Lebanon's 15-year civil war that ended in 1990, battling Syrian forces that intervened to assist Christian militias against their Muslim and leftist rivals.

Maragha rebelled against Arafat in 1982, after Israel invaded southern Lebanon and bombed the capital, Beirut, pushing out Palestinian fighters. Arafat and much of the Palestinian leadership fled to establish a base in Tunisia. Other fighters fled to Algeria and Yemen.

Maragha wanted Arafat to hold military commanders accountable for fleeing from the fighting. He argued against leaving Beirut, wanting to stay as close as possible to Israel's borders.

A year later, he established a rival group, called "Fatah Uprising." The group received the backing of the Assad regime in Syria, which sought to weaken Arafat.

He ultimately left to Damascus, where he joined the Syria-allied Palestinian National Alliance, a group that rejected negotiations with Israel.

The alliance failed to gain significant traction among Palestinians.

Maragha slowly slipped into obscurity following interim peace accords signed between Arafat's Palestine Liberation Organization and Israel, starting in 1993.

He was born in the biblical village of Bethany, near Jerusalem, a Palestinian town known now by its Arabic name, Azariyeh.

It was not immediately clear where or when Maragha would be buried. Representatives said there was heavy fighting between Syrian rebels and government forces around the cemetery in the Palestinian refugee camp of Yarmouk in Damascus.

He is survived by four children.

___

Mohammed Daraghmeh contributed reporting from Ramallah, West Bank.

Source: http://news.yahoo.com/palestinian-fighter-rebel-dies-damascus-164602325.html

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French troops take another objective in Mali

SEVARE, Mali (AP) ? French forces took control the airport in Kidal, seizing a key position in the last remaining urban stronghold of Islamist extremists in northern Mali, officials said Wednesday, with France's foreign minister said French forces would depart Mali "quickly."

French and Malian troops have recaptured two of the other provincial capitals, Timbuktu and Gao, in recent days. Once France, with its thousands of troops, fighter planes and helicopters, leaves, Mali's weak army and soldiers from neighboring countries Islamists might be hard-pressed to retain control of northern Mali's cities if the Islamists attempt a comeback from their desert hideouts.

"Now it's up to African countries to take over," French Foreign Minister Laurent Fabius told Le Parisien newspaper. "We decided to put the means ? in men and supplies ? to make the mission succeed and hit hard. But the French aspect was never expected to be maintained. We will leave quickly."

Haminy Maiga, the interim president of the Kidal regional assembly, said French forces met no resistance when they arrived late Tuesday.

"The French arrived at 9:30 p.m. aboard four planes, which landed one after another. Afterwards they took the airport and then entered the town, and there was no combat," said Maiga, who had been in touch with people in the town by satellite phone as all the normal phone networks were down.

"The French are patrolling the town and two helicopters are patrolling overhead," he added.

In Paris, French army Col. Thierry Burkhard confirmed that the airport was taken overnight and described the operation in Kidal itself as "ongoing."

On Tuesday, a secular Tuareg rebel group had asserted that they were in control of Kidal and other small towns in northern Mali. Maiga said those fighters had left Kidal and were at the entry posts on the roads from Gao and Tessalit.

France, the former colonial ruler, began sending in troops, helicopters and warplanes on Jan. 11 to turn the tide after the armed Islamists began encroaching on the south, toward the capital. French and Malian troops seized Gao during the weekend and took Timbuktu on Monday. The Islamists gave up both cities and retreated into the surrounding desert.

In Gao's main market, women returned to work on Wednesday without the black veils required by the Islamists. They wore vibrant patterned fabrics and sported makeup.

While most crowds in the freed cities have been joyful, months of resentment toward the Islamists bubbled into violence in Gao.

Video footage filmed by an amateur cameraman and obtained by The Associated Press shows a mob attacking the symbol of the oppressive regime, the Islamic police headquarters.

Some celebrate cheering "I am Malian," while others armed with sticks and machetes attack suspected members of the Islamist regime. The graphic images shot Saturday show the mob as they mutilate the corpses of two young suspected jihadists lying dead in the street.

Gao's mayor and governor met Wednesday with community elders in an attempt to bring a halt to the vigilante attacks.

There are 3,500 French troops involved in the operation and 2,900 Africans, according to the latest figures from the French Defense Ministry.

Mali's military was severely affected by a military coup last year coup and has a reputation for disorganization and bad discipline. Malian soldiers have been accused of fatally shooting civilians suspected of links to the Islamists. The military has promised to investigate the allegations.

___

Associated Press writers Baba Ahmed in Segou, Mali; Lori Hinnant in Paris; and Andrew Drake and Jerome Delay in Gao, Mali contributed to this report.

Source: http://news.yahoo.com/french-troops-another-objective-mali-124838664.html

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Tuesday, January 29, 2013

Taco Bell pulls anti-veggie ad after protest

Taco Bell's anti-veggie, pro-taco ad prompted angry tweets and other forms of protest from public health groups, who condemned what they called Taco Bell's anti-veggie propaganda.

By Associated Press / January 28, 2013

Trucks go through the drive-through at a Taco Bell restaurant in Richmond, Va., Wednesday, June 6, 2012. Taco Bell recently pulled an ad dubbed "anti-veggie" by public health advocacy groups.

Steve Helber / AP

Enlarge

Taco?Bell?is pulling a TV ad after receiving complaints that it discouraged people from eating vegetables.

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The ad by the fast-food chain was touting its variety 12-pack of?tacos, with a voiceover saying that bringing a vegetable tray to a party is "like punting on fourth and one." It said that people secretly hate guests who bring vegetables to parties.

The Center for Science in the Public Interest, a health advocacy group, this weekend urged people to tweet their complaints about the ad and the chain quickly made the decision to pull it.

"We didn't want anyone to misinterpret the intent of the ad," says Rob Poetsch, a?Taco?Bell?spokesman.

The Center for Science in the Public Interest thanked?Taco?Bell?for its speedy response.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/-wSioaMPmeY/Taco-Bell-pulls-anti-veggie-ad-after-protest

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Tesla CEO extends help to Boeing on battery issue

DETROIT (Reuters) - Elon Musk has long considered Tesla Motors Inc the bold, nimble answer to the auto industry's cautious culture. Now the electric car maker's top executive has extended his help to another industrial giant: Boeing Co .

In a January 26 message on Twitter, Musk said he was in talks with the chief engineer of Boeing's 787 Dreamliner plane, which regulators have grounded indefinitely after a string of malfunctions ranging from fuel leaks to battery meltdowns.

"Desire to help Boeing is real & am corresponding w 787 chief engineer," Musk wrote on the social media website.

Musk, who is the CEO of space transport company SpaceX, and Tesla, which aims to earn its first-ever quarterly profit later this year, did not immediately respond to requests for comment. Boeing declined to comment or confirm if such discussions were taking place.

Boeing's chief 787 engineer, Mike Sinnett, has recently made presentations about the plane and its battery technology to reporters and industry leaders.

Musk's post came a week after his first dispatch to Boeing on January 18: "Maybe already under control, but Tesla & SpaceX are happy to help with the 787 lithium ion batteries."

U.S. and Japanese authorities are investigating a fire and a smoke incident with lithium-ion batteries on two separate Dreamliners in recent weeks. The 50 Dreamliners in service cannot be flown until the U.S. Federal Aviation Administration is satisfied that the problem with the batteries has been fixed. The U.S. National Transportation Safety Board is still investigating what caused the first battery to catch fire.

Lithium-ion batteries are widely used in phones and hybrid cars because they are lighter and more powerful than traditional batteries. But if managed improperly, lithium-ion batteries can explode or catch fire, and some pose a greater risk than others depending on their chemical make-up.

The 787 is the first passenger jet to use lithium-ion batteries for back-up and auxiliary power. Tesla began using lithium-ion batteries in its Roadster, a two-door sports car that Tesla said could go from 0 to 60 miles per hour in about 4 seconds.

In its Dreamliner, Boeing adopted a lithium cobalt oxide chemistry similar to that used in the Roadster, which Tesla produced from 2008 until last year.

Musk, a serial entrepreneur who gained fame after selling his Internet payment company PayPal to eBay Inc in 2002, has been quick to criticize the cultures of major car makers like General Motors Co and Ford Motor Co .

In a magazine interview with Esquire late last year, Musk was similarly critical of Boeing. He was quoted as saying, "You know the joke about Boeing: It puts the zero in being."

Musk later took pains to dismiss the story, written by reporter Tom Junod. "Junod's Esquire article had high fiction content," Musk wrote his January 26 tweet.

Junod said Musk's dig at Boeing was on tape and his story was "more extensively reported than any story on Elon that preceded it."

(Reporting By Deepa Seetharaman; additional reporting by Nichola Groom and Alwyn Scott; Editing by Alwyn Scott and Chris Gallagher)

Source: http://news.yahoo.com/tesla-ceo-extends-help-boeing-battery-issue-021018479--sector.html

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Survival of the prettiest: Sexual selection can be inferred from the fossil record

Jan. 29, 2013 ? Detecting sexual selection in the fossil record is not impossible, according to scientists writing in Trends in Ecology and Evolution this month, co-authored by Dr Darren Naish of the University of Southampton.

The term "sexual selection" refers to the evolutionary pressures that relate to a species' ability to repel rivals, meet mates and pass on genes. We can observe these processes happening in living animals but how do palaeontologists know that sexual selection operated in fossil ones?

Historically, palaeontologists have thought it challenging, even impossible, to recognise sexual selection in extinct animals. Many fossil animals have elaborate crests, horns, frills and other structures that look like they were used in sexual display but it can be difficult to distinguish these structures from those that might play a role in feeding behaviour, escaping predators, controlling body temperature and so on.

However in their review, the scientists argue that clues in the fossil record can indeed be used to infer sexual selection.

"We see much evidence from the fossil record suggesting that sexual selection played a major role in the evolution of many extinct groups," says Dr Naish, of the University's Vertebrate Palaeontology Research Group.

"Using observations of modern animal behaviour we can draw analogies with extinct animals and infer how certain features improve success during courtship and breeding."

Modern examples of sexual selection, where species have evolved certain behaviours or ornamentation that repel rivals and attract members of the opposite sex, include the male peacock's display of feathers, and the male moose's antlers for use in clashes during mating season.

Dr Naish and co-authors state that the fossil record holds many clues that point to the existence of sexual selection in extinct species, for example weaponry for fighting, bone fractures from duels, and ornamentation for display, such as fan-shaped crests on dinosaurs. Distinct differences between males and females of a species, called 'sexual dimorphism', can also suggest the presence of sexual selection, and features observed in sexually mature adults, where absent from the young, indicate that their purpose might be linked to reproduction.

We can also make inferences from features that are 'costly' in terms of how much energy they take to maintain, if we assume that the reproductive advantages outweighed the costs.

Whilst these features might have had multiple uses, the authors conclude that sexual selection should not be ruled out.

"Some scientists argue that many of the elaborate features on dinosaurs were not sexually selected at all," adds Dr Naish, who is based at the National Oceanography Centre, Southampton.

"But as observations show that sexual selection is the most common process shaping evolutionary traits in modern animals, there is every reason to assume that things were exactly the same in the distant geological past."

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The above story is reprinted from materials provided by University of Southampton.

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Journal Reference:

  1. Robert J. Knell, Darren Naish, Joseph L. Tomkins, David W.E. Hone. Sexual selection in prehistoric animals: detection and implications. Trends in Ecology & Evolution, 2013; 28 (1): 38 DOI: 10.1016/j.tree.2012.07.015

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/EIyoP0e6xn8/130129080217.htm

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Monday, January 28, 2013

Less invasive treatment may increase survival in early stage breast cancer

Less invasive treatment may increase survival in early stage breast cancer [ Back to EurekAlert! ] Public release date: 28-Jan-2013
[ | E-mail | Share Share ]

Contact: Rachel Harrison
rachel.harrison@duke.edu
919-419-5069
Duke University Medical Center

DURHAM, N.C. -- Patients with early stage breast cancer who are treated with lumpectomy plus radiation have a better chance of survival compared with those who undergo mastectomy, according to Duke Medicine research.

The study, which appears online Jan. 28, 2013, in the journal CANCER, demonstrates the effectiveness of breast-conserving therapies such as lumpectomy, where only the tumor and surrounding tissue are surgically removed.

"Our findings support the notion that less invasive treatment can provide superior survival to mastectomy in stage I or stage II breast cancer," said E. Shelley Hwang, M.D., MPH, chief of breast surgery at Duke Cancer Institute and the study's lead author.

Using 14 years of data from the California Cancer Registry, a source of long-term outcome data for cancer, the research team found improved survival to be associated with the less invasive treatment in all age groups, as well as those with both hormone-sensitive and hormone-resistant cancers. Women age 50 and older at diagnosis with hormone-sensitive tumors saw the largest benefit of choosing lumpectomy plus radiation: they were 13 percent less likely to die from breast cancer, and 19 percent less likely to die from any cause compared with those undergoing mastectomy.

Prior research has shown that lumpectomy with radiation is as effective as mastectomy in treating early stage breast cancer. As a result, the rate of women electing lumpectomy with radiation has climbed in the past few decades.

However, a recent trend has emerged with some early stage breast cancer patients, often younger women, opting for mastectomy. These women may perceive mastectomy to be more effective at eliminating early stage cancer and therefore reducing the anxiety accompanying long-term surveillance.

"Given the recent interest in mastectomy to treat early stage breast cancers, despite the research supporting lumpectomy, our study sought to further explore outcomes of breast-conserving treatments in the general population comparing outcomes between younger and older women," Hwang said.

The team analyzed data from 112,154 women diagnosed with stage I or stage II breast cancer between 1990 and 2004, including 61,771 who received lumpectomy and radiation and 50,383 who had mastectomy without radiation. They looked at age and other demographic factors, along with tumor type and size to decipher whether each treatment had better outcomes for certain groups of women. Patients were followed on average for 9.2 years.

The researchers evaluated whether illnesses other than breast cancer, such as heart and respiratory disease, may have influenced whether women chose lumpectomy or mastectomy. Within three years of diagnosis, breast cancer patients who underwent lumpectomy and radiation had higher survival rates than those who chose mastectomy when all other illnesses were evaluated. This suggests that women choosing lumpectomy may have been generally healthier.

Hwang and her colleagues were surprised to also find that early stage breast cancer patients treated with mastectomy had a significantly lower survival rate from breast cancer than women who underwent lumpectomy with radiation.

"We found that lumpectomy plus radiation was an effective alternative to mastectomy for early stage disease, regardless of age or tumor type," said Hwang. "Even patients we thought might benefit less from localized treatment, like younger patients with hormone-resistant disease, can remain confident in lumpectomy as an equivalent and possibly better treatment option."

###

In addition to Hwang, study authors include Daphne Y. Lichtensztajn, Scarlett Lin Gomez, and Christina A. Clarke of the Cancer Prevention Institute of California. Barbara Fowble of the University of California San Francisco Helen Diller Family Comprehensive Cancer Center also contributed to the research.

The study was supported by National Cancer Institute's Surveillance, Epidemiology and End Results Program (HHSN261201000140C) awarded to the Cancer Prevention Institute of California. The collection of cancer incidence data used in this study was supported by the California Department of Health Services.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Less invasive treatment may increase survival in early stage breast cancer [ Back to EurekAlert! ] Public release date: 28-Jan-2013
[ | E-mail | Share Share ]

Contact: Rachel Harrison
rachel.harrison@duke.edu
919-419-5069
Duke University Medical Center

DURHAM, N.C. -- Patients with early stage breast cancer who are treated with lumpectomy plus radiation have a better chance of survival compared with those who undergo mastectomy, according to Duke Medicine research.

The study, which appears online Jan. 28, 2013, in the journal CANCER, demonstrates the effectiveness of breast-conserving therapies such as lumpectomy, where only the tumor and surrounding tissue are surgically removed.

"Our findings support the notion that less invasive treatment can provide superior survival to mastectomy in stage I or stage II breast cancer," said E. Shelley Hwang, M.D., MPH, chief of breast surgery at Duke Cancer Institute and the study's lead author.

Using 14 years of data from the California Cancer Registry, a source of long-term outcome data for cancer, the research team found improved survival to be associated with the less invasive treatment in all age groups, as well as those with both hormone-sensitive and hormone-resistant cancers. Women age 50 and older at diagnosis with hormone-sensitive tumors saw the largest benefit of choosing lumpectomy plus radiation: they were 13 percent less likely to die from breast cancer, and 19 percent less likely to die from any cause compared with those undergoing mastectomy.

Prior research has shown that lumpectomy with radiation is as effective as mastectomy in treating early stage breast cancer. As a result, the rate of women electing lumpectomy with radiation has climbed in the past few decades.

However, a recent trend has emerged with some early stage breast cancer patients, often younger women, opting for mastectomy. These women may perceive mastectomy to be more effective at eliminating early stage cancer and therefore reducing the anxiety accompanying long-term surveillance.

"Given the recent interest in mastectomy to treat early stage breast cancers, despite the research supporting lumpectomy, our study sought to further explore outcomes of breast-conserving treatments in the general population comparing outcomes between younger and older women," Hwang said.

The team analyzed data from 112,154 women diagnosed with stage I or stage II breast cancer between 1990 and 2004, including 61,771 who received lumpectomy and radiation and 50,383 who had mastectomy without radiation. They looked at age and other demographic factors, along with tumor type and size to decipher whether each treatment had better outcomes for certain groups of women. Patients were followed on average for 9.2 years.

The researchers evaluated whether illnesses other than breast cancer, such as heart and respiratory disease, may have influenced whether women chose lumpectomy or mastectomy. Within three years of diagnosis, breast cancer patients who underwent lumpectomy and radiation had higher survival rates than those who chose mastectomy when all other illnesses were evaluated. This suggests that women choosing lumpectomy may have been generally healthier.

Hwang and her colleagues were surprised to also find that early stage breast cancer patients treated with mastectomy had a significantly lower survival rate from breast cancer than women who underwent lumpectomy with radiation.

"We found that lumpectomy plus radiation was an effective alternative to mastectomy for early stage disease, regardless of age or tumor type," said Hwang. "Even patients we thought might benefit less from localized treatment, like younger patients with hormone-resistant disease, can remain confident in lumpectomy as an equivalent and possibly better treatment option."

###

In addition to Hwang, study authors include Daphne Y. Lichtensztajn, Scarlett Lin Gomez, and Christina A. Clarke of the Cancer Prevention Institute of California. Barbara Fowble of the University of California San Francisco Helen Diller Family Comprehensive Cancer Center also contributed to the research.

The study was supported by National Cancer Institute's Surveillance, Epidemiology and End Results Program (HHSN261201000140C) awarded to the Cancer Prevention Institute of California. The collection of cancer incidence data used in this study was supported by the California Department of Health Services.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-01/dumc-lit012413.php

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Olympic Torch lights up Sligos Peace Mini Olympics : Sligo Sport ...

An Olympic torch was the highlight of Sligo?s Mini Olympics last week (4th ?Dec) when 100 primary school pupils took part in non-competitive games organized by Sligo Sports and Recreation Partnership. The Sligo Mini Olympics are designed to increase awareness and understanding of cultural diversity and encourage inclusive celebration among young people.

sligo-mini-olympics-low-res-3011

The Sligo Mini Olympics are funded by the PEACE III Programme through the European Union?s European Regional Development Fund managed for the Special EU Programmes Body by Sligo County Council on behalf of Sligo Peace and Reconciliation Partnership Committee. They were organized by Sligo Sport and Recreation Partnership, which is part of the Urban Peace Collective, a project of the PEACE III programme.

The Olympic torch was brought to Sligo by the Irish Sports Council Sports Partnership Officer Michelle Harte, who was a special guest at the event.

Five primary schools, Our Lady of Mercy P.S, St Edward?s N.S, St Brendan?s N.S, St John?s School and Sligo School Project took part in the Mini Olympics. Children at each school received coaching sessions in preparation for the event. Each school represented a country at the Mini Olympics and developed its own flags and banners for the event.

The young athletes took part in hurdles, speed bounce, javelin, hammer, long jump and rebounder relays in mixed teams with pupils from other schools, without the focus of competition.

?Sligo Sport and Recreation Partnership were delighted to have Michelle Harte from the Irish Sports Council as our special guest. The Olympic Games are the world?s greatest multi-cultural sporting spectacle and are a means to inspire, stimulate and promote positive messages and good practice through sport,? said Diane Middleton of Sligo Sports and Recreation Partnership.For further information on this initiative please contact Diane Middleton, Sligo Sport and Recreation Partnership on 071-9161511 or email diane@sligosportandrecreation.ie.

sligo-mini-olympics-low-res-2979

Source: http://www.sligosportandrecreation.ie/2013/01/olympic-torch-lights-up-sligos-peace-mini-olympics/

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Source: http://gavin9505.typepad.com/blog/2013/01/olympic-torch-lights-up-sligos-peace-mini-olympics-sligo-sport.html

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How You Can Benefit from a Business Communication Course

Effective business communication starts with finding your voice and the right tone for a specific audience.

Business memos, letters and reports can benefit from an authoritative, expert style. When you can write and communicate well within your industry and with your clients, your professional peers will take notice, and you may begin to rise through the ranks.

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Speak Effectively, Accomplish More

Effective communications can increase workplace productivity. Time is money when it comes to explaining details to others, and your communication skills can pay off when you speak clearly and communicate well with peers either in your office or with a global team.

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Other Aspects of Business Communication

To gain a level of confidence in oral and written communications, courses focusing on these skills can be beneficial. If you are shy or withdrawn and feel uncomfortable communicating to a large audience, taking a course can help in the following ways:

  • Gain basic writing skills: With these courses, you can improve your writing and develop your skills in writing informational, persuasive communications. The more you practice, the faster and easier this task may become.
  • Find your voice: You can learn the distinctions of a writing voice for an internal or external audience including nuances that resonate whether you are speaking to coworkers or clients.
  • Become more comfortable engaging others: Having a relaxed attitude is valuable when you are meeting with peers at conferences or taking a lead role in meetings. Your abilities and poise under pressure can help set the tone for the rest of the room.

Mediate, Motivate

Learning more about how to effectively discuss issues with others can be important in areas such as mediation. You may draw from all of your communication knowledge that you acquire in a basic course to inspire, manage conflicts in an office setting and keep everyone on task.

Business Communication?Training?Can Help You Update Your Job Skills

Business communication is more than just speaking and writing. Adopting new communication skills can put you on the leading edge of industry public relations and could help you build a new career with advanced skill sets.

Other elements that a basic course could introduce you to may include:

  • Desktop publishing and managing websites and blogs: Not only can you learn more about Web technology but also learn different ways to create effective content for a company website or blog.
  • Video conferencing using Google Hangouts, Skype or FaceTime: Verbal skills can shine in these arenas once you learn the fundamentals of presentation and delivering a clear message.
  • Social media cultivation and management: This growing field is becoming more important for businesses in terms of marketing, promotion and reputation management.

Business leaders are those who can rise to the challenge and present a charismatic version of themselves to the public through their verbal skills and ability to write effectively.

Your journey on this path could begin with what you learn initially in a basic business communication course. Your first lessons could be the foundation for future growth in your career.

Source: http://effectivecommunicationadvice.com/how-you-can-benefit-from-a-business-communication-course

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Sunday, January 27, 2013

edrisali1990: norine dart: Health Plus Fitness: Womens Issues ...

norine dart: Health Plus Fitness: Womens Issues Article Category ...

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Source: http://norine-dart.blogspot.com/2013/01/health-plus-fitness-womens-issues.html

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Source: http://edrisali1990.blogspot.com/2013/01/norine-dart-health-plus-fitness-womens.html

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Professor: Take our country back, from the Constitution (cbsnews)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, News Feeds and News via Feedzilla.

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Consumer alert: new health care markets on the way

WASHINGTON (AP) ? Buying your own health insurance will never be the same.

This fall, new insurance markets called exchanges will open in each state, marking the long-awaited and much-debated debut of President Barack Obama's health care overhaul.

The goal is quality coverage for millions of uninsured people in the United States. What the reality will look like is anybody's guess ? from bureaucracy, confusion and indifference to seamless service and satisfied customers.

Exchanges will offer individuals and their families a choice of private health plans resembling what workers at major companies already get. The government will help many middle-class households pay their premiums, while low-income people will be referred to safety-net programs they might qualify for.

Most people will go online to pick a plan when open enrollment starts Oct. 1. Counselors will be available at call centers and in local communities, too. Some areas will get a storefront operation or kiosks at the mall. Translation to Spanish and other languages spoken by immigrants will be provided.

When you pick a plan, you'll no longer have to worry about getting turned down or charged more because of a medical problem. If you're a woman, you can't be charged a higher premium because of gender. Middle-aged people and those nearing retirement will get a price break: They can't be charged more than three times what younger customers pay, compared with six times or seven times today.

If all this sounds too good to be true, remember that nothing in life is free and change isn't easy.

Starting Jan. 1, 2014, when coverage takes effect in the exchanges, virtually everyone in the country will be required by law to have health insurance or face fines. The mandate is meant to get everybody paying into the insurance pool.

Obama's law is called the Affordable Care Act, but some people in the new markets might experience sticker shock over their premiums. Smokers will face a financial penalty. Younger, well-to-do people who haven't seen the need for health insurance may not be eligible for income-based assistance with their premiums.

Many people, even if they get government help, will find that health insurance still doesn't come cheaply. Monthly premiums will be less than the mortgage or rent, but maybe more than a car loan. The coverage, however, will be more robust than most individual plans currently sold.

Consider a hypothetical family of four making $60,000 and headed by a 40-year-old. They'll be eligible for a government tax credit of $7,193 toward their annual premium of $12,130. But they'd still have to pay $4,937, about 8 percent of their income, or about $410 a month.

A lower-income family would get a better deal from the government's sliding-scale subsidies.

Consider a similar four-person family making $35,000. They'd get a $10,742 tax credit toward the $12,130 annual premium. They'd have to pay $1,388, about 4 percent of their income, or about $115 a month.

The figures come from the nonpartisan Kaiser Family Foundation's online Health Reform Subsidy Calculator. But while the government assistance is called a tax credit and computed through the income tax system, the money doesn't come to you in a refund. It goes directly to insurers.

Obama's law is the biggest thing that's happened to health care since Medicare and Medicaid in the 1960s. But with open enrollment for exchange plans less than 10 months away, there's a dearth of consumer information. It's as if the consumer angle got drowned out by the political world's dispute over "Obamacare," the dismissive label coined by Republican foes.

Yet exchanges are coming to every state, even those led by staunch GOP opponents of the overhaul, such as Govs. Rick Perry of Texas and Nikki Haley of South Carolina. In their states and close to 20 others that are objecting, the exchanges will be operated by the federal government, over state opposition. Health and Human Services Secretary Kathleen Sebelius has pledged that every citizen will have access to an exchange come next Jan. 1, and few doubt her word.

But what's starting to dawn on Obama administration officials, activists, and important players in the health care industry is that the lack of consumer involvement, unless reversed, could turn the big health care launch into a dud. What if Obama cut the ribbon and nobody cared?

"The people who stand to benefit the most are the least aware of the changes that are coming," said Rachel Klein, executive director of Enroll America, a nonprofit that's trying to generate consumer enthusiasm.

"My biggest fear is that we get to Oct. 1 and people haven't heard there is help coming, and they won't benefit from it as soon as they can," she added. "I think it is a realistic fear."

Even the term "exchange" could be a stumbling block. It was invented by policy nerds. Although the law calls them "American Health Benefit Exchanges," Sebelius is starting to use the term "marketplaces" instead.

Polls underscore the concerns. A national survey last October found that only 37 percent of the uninsured said they would personally be better off because of the health care law. Twenty-three percent said they would be worse off in the Kaiser poll, while 31 percent said it would make no difference to them.

Insurers, hospitals, drug companies and other businesses that stand to benefit from the hundreds of billions of dollars the government will pump in to subsidize coverage aren't waiting for Washington to educate the public.

Blue Cross and Blue Shield plans, for example, are trying to carve out a new role for themselves as explainers of the exchanges. Somewhere around 12 million people now purchase coverage individually, but the size of the market could double or triple with the new approach, and taxpayers will underwrite it.

"Consumers are expecting their health insurance provider to be a helpful navigator to them," said Maureen Sullivan, a senior vice president for the Blues' national association. "We see 2013 as a huge year for education."

One goal is to help consumers master the "metals," the four levels of coverage that will be available through exchange plans ? bronze, silver, gold, and platinum.

Blue Cross is also working with tax preparer H&R Block, which is offering its customers a health insurance checkup at no additional charge this tax season. Returns filed this year for 2012 will be used by the government to help determine premium subsidies for 2014.

"This tax season is one of historical significance," said Meg Sutton, senior advisor for tax and health care at H&R Block. "The tax return you are filing is going to be key to determining your health care benefits on the exchange."

Only one state, Massachusetts, now has an exchange resembling what the administration wants to see around the country. With six years in business, the Health Connector enrolls about 240,000 Massachusetts residents. It was created under the health overhaul plan passed by former Republican Gov. Mitt Romney and has gotten generally positive reviews.

Connector customer Robert Schultz is a Boston area startup business consultant who got his MBA in 2008, when the economy was tanking. Yet he was able to find coverage when he graduated and hang on to his insurance through job changes since. Schultz says that's freed him to pursue his ambition of becoming a successful entrepreneur ? a job creator instead of an employee.

"It's being portrayed by opponents as being socialistic," Schultz said.. "It is only socialistic in the sense of making sure that everybody in society is covered, because the cost of making sure everybody is covered in advance is much less than the cost of putting out fires."

The Connector's executive director, Glen Shor, said his state has proven the concept works and he's confident other states can succeed on their own terms.

"There is no backing away from all the challenges associated with expanding coverage," Shor said. "We are proud in Massachusetts that we overcame what had been years of policy paralysis."

___

Online:

Kaiser Health Reform Subsidy Calculator - http://healthreform.kff.org/subsidycalculator.aspx

EDITOR'S NOTE _ This is the first story in a two-part series that provides an overview of the major changes in health insurance facing Americans under the Affordable Care Act, President Barack Obama's health care overhaul.

Source: http://news.yahoo.com/consumer-alert-health-care-markets-way-131508179--finance.html

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Saturday, January 26, 2013

Gregory Charles to receive Martin Luther King Jr. Award

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?I?m a parent now and I appreciate even more now what my parents did for me and for the role models they were.? says Gregory Charles.

Photograph by: Peter Ford

MONTREAL - Not that he doesn?t appreciate all the wonderful things that have come his way in this city, but it?s days like this when Gregory Charles wonders what it would be like if his family had stayed put in Trinidad where the temperature is about ? mmm ? 70 degrees warmer.

?Half of my family grew up in a place where it?s 36 degrees every day of the year,? Charles notes. ?The other half of my family had it worse. Still my maternal grandparents and great-grandparents from Quebec would probably hit me across the head if I were to complain about the weather. Besides, it could be worse, and it has been worse here.?

Ah, spoken like a true Montrealer.

Charles allows that perhaps it was the elements as well as the determination of his family that pushed him into overachieving and becoming as close as anyone in these parts to being a modern-day Renaissance man. Charles is an award-winning singer, musician, actor, choir director, radio and TV host, teacher and, oh yeah, lawyer. Almost easier to list the occupations he doesn?t have.

Charles is about to add another credit to his r?sum?. On Saturday evening at the downtown La Plaza Holiday Inn, he will be presented the Dr. Martin Luther King Jr. Achievement Award at the 27th Vision Celebration Gala, which is held annually by the Black Theatre Workshop to kick off Black History Month festivities in Montreal in February. Charles is being honoured not only for his international artistic success, but also for his community involvement. He joins an impressive list of past award winners: Oscar Peterson, Oliver Jones, Ranee Lee and Trevor Payne, among other notables.

Charles will warm up the crowd Saturday night by tickling the ivories complemented by some inspired crooning. Also on the performing bill will be 12-year-old classical piano prodigy Daniel Clarke Bouchard, who brought the house down at Place des Arts in December at the 30th anniversary Montreal Jubilation Gospel Choir Christmas concert.

?I?m obviously very proud about the award, but in a funny way, I?m even prouder for my dad. I?m a parent now and I appreciate even more now what my parents did for me and for the role models they were. So when I?m recognized for the work I have done with kids and artists as a community-involved person, my first reflex is to think who my models have been. My dad used to tell me: ?If you can walk, run. If you know, teach.? And this has applied to pretty much everything I?ve done.

?My parents were just perfect. My mom was my general and so honest and demanding. I could always trust her to tell me how she felt. My dad was so positive and socially so astute. Everybody who has ever spoken to my dad feels like they?re the most important person on the planet. He made me feel like I could accomplish anything I set my mind to.?

Charles also points out that his parents would always stress for him to think in terms of ?team? ? and not individual goals. He hopes to impart the same philosophy to his year-old daughter when she grows up. Charles credits his wife, Nicole, a Microsoft exec, for keeping the family on an even keel.

An overachiever, too? ?Let?s say she?s an ambitious person. I can never admit to being an overachiever, either. But I can admit to being very ambitious, that life is more interesting when you follow Captain Cook?s credo: which is not to go any further than anybody else, but to go as far as is possible. And love whatever you do with all your heart and all your soul.?

He recalls how his mother used to decry the word ?satisfaction.? She felt it ?unbearable? that it meant to do ?enough.? She thought the word should be linked to doing ?everything in one?s power.?

Even by his mom?s strict definition, Charles has to feel satisfied. He began early. When he was 7, he won a piano contest at the Canadian Music Competition. After performing with symphony orchestras around the country, he would later apply his piano skills on tour with C?line Dion before breaking out as a solo act.

Charles now does about 200 concerts a year around the planet. He is forever hosting variety shows as well as his TV and radio programs. His first one-man show, Black and White, has played to more than one million people, and he holds the house record at the Bell Centre for doing it 43 times. The show also hit the legendary Carlyle Caf? in New York and received glorious plaudits from The New York Times.

One could go about his record sales, acting accomplishments, awards ? including two F?lix prizes for best stage show and best male singer. He is a judge on and a member of the teaching faculty of Star Acad?mie. He is founder and president of the Mondial Loto-Qu?bec de Laval. Plus, he is also head of the Gregory Foundation, a local charity that offers support to young Canadians in the arts. He has been teaching aspiring artists for the last 18 years. He has also been involved with specialty music and science summer camps for kids as well as programs for inner-city kids in St. Henri. To those ends, he does about 30 fundraisers a year.

And can?t forget that Charles also has a doctoral degree in civil law.

OK, so he?s not a medical doctor ? yet. But there?s still time. He?s only 44.

Charles is also one of the few who is a fixture in both the anglo and franco cultural communities.

?I?ve been lucky to receive such rich culture from both my French-Canadian and English-Canadian families,? says Charles, whose cousin Kevin Brereton is the well-known rapper k-os. ?Add to that, my Caribbean background. I have been so enriched by all these components and all these people. And I do believe my constant desire to better myself is a result of my roots.

?I don?t expect to be given the key to heaven for what I?ve done. I?m simply the result of what my parents made and I?ve followed through on what they taught me.? Pause. ?And even being a lawyer proves one can still turn out to be a decent person,? he cracks.

?Actually, I probably would have turned out to be a really lousy lawyer had I chosen to continue on that path. But it also connects with who I am. Lawyers are taught to believe in possibilities, and that principle has guided me. I don?t believe it?s possible to change the world, but I do believe that when you apply yourself, it?s possible to change your world. And the way to do that is to move people, be it by song, words or deeds.?

Charles passes down advice he picked up from then-young vedette Ren? Simard several decades back: ?I asked him how one makes it in showbiz. His response: ?Never say no.? I was a little disappointed with the answer then. But I learned to appreciate it later.?

And Charles rarely says no, be it to gigs, fundraisers or doing national anthems at Habs games.

?Talk about pressure. If you sing and they lose ? as they did against the Leafs last Saturday when I sang ? they won?t want to see my face again.

?It proves you can?t get too smug in this business.?

The Black Theatre Workshop?s 27th Vision Celebration Gala takes place Saturday at La Plaza Holiday Inn, 420 Sherbrooke St. W. Cocktails are at 5:30 p.m., followed by dinner at 6:30 p.m. Gregory Charles will be presented with the Dr. Martin Luther King Jr. Achievement Award. Charles and pianist Daniel Clarke Bouchard will perform. For tickets, call 514-932- 1104 ext. 225. For more information, go to blacktheatreworkshop.ca

bbrownstein@montrealgazette.com?

Twitter: @billbrownstein

? Copyright (c) The Montreal Gazette

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Source: http://www.montrealgazette.com/entertainment/music/Bill+Brownstein+Gregory+Charles+receive+Martin/7872594/story.html

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Alt-week 1.26.13: quadruple DNA helixes, Byzantine mutants and battling hospital bugs

Alt-week takes a look at the best science and alternative tech stories from the last seven days.

Altweek 12613 quadruple DNA helixes, Byzantine mutants and battling hospital bugs

In isolation, this week's stories are all pretty notable, but if you put them together, it begins to sound a lot like the plot of a movie. Four-stranded DNA, a database of alien planets, a new super-chemical to kill hospital bugs and a byzantine gamma-radiation blast. You can almost picture the plucky heroine trying to unpick the galactic conspiracy before someone loses an eye -- and if you've already cast weepy Clare Danes in the role, then you've already passed the entry exam to read Alt-week.

NASA's Kepler observatory is designed to explore strange new worlds, seek out new life and civilizations traces of exoplanets and has clocked up around two thousand unconfirmed sightings. The team behind the program have decided to lessen the workload by opening up its findings and letting armchair astronomers worldwide participate. As well as being able to chip in with opinions about what constitutes a planet, the team are letting students develop data mining experiments, looking for patterns that could assist in the discovery of alien life -- or just look neat when graphed visually.

DNP Altweek 12613

Scientists think that a blast of Gamma radiation might have hit our planet in the halcyon days of the year 775. Fusa Miyake discovered Carbon-14 and Beryllium-10 traces in tree rings from the era, which point to a gamma ray burst from a celestial body other than the Sun. Of course, the natural question is why we have no recorded instances of Dr. Brvce Banner turning green and smashing up Byzantine Constantinople? Well, it seems that astrophysicist Ralph Neuhauser has the unexciting answer -- most of the radiation would have been caught by the atmosphere, meaning that it's highly unlikely anyone succumbed to an accidental overdose.

DNP Altweek 12613

Hospital bugs like MRSA are easy to kill when they're outside your body, just as long as you've got some alcohol nearby. If they get inside you, then there's always the option of taking an antibiotic or two to kill 'em off. If, however, they've hitched a ride on a catheter that's implanted into your body, then the bugs can grow a biofilm -- in short, a biological beachhead that will constantly reinfect you and is impenetrable to antibiotics. IBM, in partnership with the Singapore Institute of Bioengineering and Nanotechnology, has developed a hydrogel that can be smeared all over such implants, greatly reducing the risk of infection. Safe enough to go into the human body, the hydrogel prevents biofilms from growing and, thanks to its positive charge, attracts negatively charged microorganisms, which it then pops like water balloons. There's no word on if Big Blue plans to share the discovery with chemical corporations, but it certainly sounds better than downing a shot of Purell every time we venture in for a check-up.

Altweek 12613 quadruple DNA helixes, Byzantine mutants and battling hospital bugs

DNA can only be found in a double helix, right? That fact seems destined for the biology section of Snopes after scientists found a quadruple helix. A team at Cambridge University used structure-specific markers to tag the G-Quadruplex, proving that these structures can exist in the human body as well as in petri dishes and in simple organisms. It transpires that they can form during cell division at the point where DNA is being replicated, and may have a hand in the development of some cancers -- meaning they're of great interest to oncologists.

Altweek 12613 quadruple DNA helixes, Byzantine mutants and battling hospital bugs

Seen any other far-out articles that you'd like considered for Alt-week? Working on a project or research that's too cool to keep to yourself? Drop us a line at alt [at] engadget [dot] com.

[Image Credit: NASA / IBM / JP Rodriguez / G.Biffi]

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/WlioyIzjAWs/

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Nestle And Childhood Obesity | Your Health Journal

From the web master?..I had the privilege of working with Nestle many years ago, so ? when a press release was emailed to me today, I wanted to share it here, as Nestle does do a lot for the communities behind the scenes. As always, if you have a health related press release, feel free to use the contact form above to send it along.

Nestle steps up efforts to help reduce childhood obesity in the US

A Nestl? programme in the city of Newark in the United States that teaches parents of young children the fundamentals of good nutrition is to be expanded.

?Nestl?/Newark Now!?, which was launched in 2012 with Newark?s Mayor Cory A. Booker, will reach twice as many families in year two. Some of the mothers and other women who went through the first programme will become ?peer educators?.

As Nestl? announced, in Newark, nearly one third of children aged 3-5 years old are classified as obese ? three times the US national average. ?Nestl?/Newark Now!? has been designed to try to address this.The programme, run by Nestl? and the community organisation Newark Now!, helps fill a ?gap? in nutrition education that occurs after the first year of post-natal doctor visits and before the child reaches school age.

A bilingual public health nutritionist leads the sessions in community centres around Newark.

Fifty-five families took part in the first year, learning about the importance of breastfeeding, how to increase fruit and vegetable consumption, healthy snacking, dealing with fussy eaters, portion control and physical activity.The curriculum was created by an advisory board made up of local nutrition and public health experts, as well as community members with experience in engaging with local residents to help manage programme content and activities.

Starting in March, parents and other women who were picked to become ?peer educators?, will begin sharing their knowledge with hundreds more families.

The Nestl?/Newark Now! curriculum draws on the findings of the Nestl? Feeding Infants & Toddlers Study (FITS).

FITS studied the dietary habits and nutrient intake of 3,200 infants, toddlers and preschoolers, making it one of the largest, most comprehensive studies of its kind in the United States.

The study found that children aged as young as 12-24 months old were beginning to develop unhealthy dietary patterns that may lead to childhood obesity.

The study also revealed fruit and vegetables were lacking in children?s diets.

At an official ceremony in the city to mark the next phase of the programme, Newark Mayor Booker and Deputy Mayor Margarita Muniz were joined by Sylvana Linetti, Nutrition Director for Nestl?/Newark Now and Marilyn Knox, CEO of Nestl? Infant Nutrition.

Lavar Young, President and Chief Executive Officer for Newark Now and Dr Anyaoku, Director General of Paediatrics for the Children?s Hospital of New Jersey at Newark Beth Israel Medical Center, also attended.

Source: http://www.lensaunders.com/wp/?p=11916

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Retrovirus in the human genome is active in pluripotent stem cells

Thursday, January 24, 2013

A retrovirus called HERV-H, which inserted itself into the human genome millions of years ago, may play an important role in pluripotent stem cells, according to a new study published in the journal Retrovirology by scientists at UMass Medical School. Pluripotent stem cells are capable of generating all tissue types, including blood cells, brain cells and heart cells. The discovery, which may help explain how these cells maintain a state of pluripotency and are able to differentiate into many types of cells, could have profound implications for therapies that would use pluripotent stem cells to treat a range of human diseases.

"What we've observed is that a group of endogenous retroviruses called HERV-H is extremely busy in human embryonic stem cells," said Jeremy Luban, MD, the David L. Freelander Memorial Professor in HIV/AIDS Research, professor of molecular medicine and lead author of the study. "In fact, HERV-H is one of the most abundantly expressed genes in pluripotent stem cells and it isn't found in any other cell types."

In the study, Dr. Luban and colleagues describe how RNA from the HERV-H sequence makes up as much as 2 percent of the total RNA found in pluripotent stem cells. The HERV-H sequence is controlled by the same factors that are used to reprogram skin cells into induced pluripotent stem (iPS) cells, a discovery that garnered the 2012 Nobel Prize in Physiology or Medicine. "In other words, HERV-H is a new marker for pluripotency in humans that has the potential to aid in the development of iPS cells and transform current stem cell technology," said Luban.

When a retrovirus infects a cell, it inserts its own genes into the chromosomal DNA of the host cell. As a result, the host cell treats the viral genome as part of its own DNA sequence and begins making the proteins required to assemble new copies of the virus. And because the retrovirus is now part of the host cell's genome, when the cell divides, the virus is inherited by all daughter cells.

In rare cases, it's believed that retroviruses can infect human sperm or egg cells. If this happens, and if the resulting embryo survives, the retrovirus can become a permanent part of the human genome, and be passed down from generation to generation. Scientists estimate that as much as 8 percent of the human genome may be comprised of extinct retroviruses left over from infections that occurred millions of years ago. Yet these sequences of fossilized retrovirus were thought to have no discernible functional value.

"The human genome is filled with retrovirus DNA thought to be no more than fossilized junk," said Luban. "Increasingly, there are indications that these sequences might not be junk. They might play a role in gene expression after all."

An expert in HIV and other retroviruses, Luban and his colleagues were seeking to understand if there was a rationale behind where, in the expansive human genome, retroviruses inserted themselves. Knowing where along the chromosomal DNA retroviruses might attack could potentially lead to the development of drugs that protect against infection; better gene therapy treatments; or novel biomarkers that would predict where a retrovirus would insert itself in the genome, said Luban.

Turning these same techniques on the retrovirus sequences already in the human genome, they discovered a sequence, HERV-H, that appeared to be active. "The sequences weren't making proteins because they had been so disrupted over millions of years, but they were making these long, noncoding RNAs," said Luban.

Specifically, the HERV-H sequence was making abundant amounts of RNA in human embryonic stem cells?and only stem cells. In total, there are more than 1,000 HERV-H retrovirus genomes scattered throughout the human genome. The Luban lab also found high levels of HERV-H RNA in some iPS cells. Other iPS cells, perhaps those lines that were not sufficiently reprogrammed to pluripotency, had lower levels of the HERV-H RNA, another indication that HERV-H may be an important marker for pluripotency.

Interestingly, the HERV-H genes that were expressed in human pluripotent stem cells are only found in the human and chimpanzee genomes, indicating that HERV-H infected a relatively recent ancestor to humans, said Luban.

"Once upon a time HERV-H was an invader to our genome and perhaps caused diseases like AIDS or cancer," said Luban. "Now it seems that a kind of d?tente has been reached. Not only that, but this ancient invader may one day be exploited by clinicians to cure people of a wide range of diseases using stem cell therapies."

Luban and colleagues will next try to determine the specific mechanisms by which HERV-H contributes to pluripotency.

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University of Massachusetts Medical School: http://www.umassmed.edu

Thanks to University of Massachusetts Medical School for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/126435/Retrovirus_in_the_human_genome_is_active_in_pluripotent_stem_cells

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